RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Thy1
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
rattus norvegicus
Detection Methods
qRT-PCR; Chromatin immunoprecipitation assay; Immunofluorescence etc.
Target
NA
Pathway
NA
PubMed ID
Title
Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts
Year
2011
Function
"Treatment with the histone deacetylase inhibitor trichostatin A (TSA) restored Thy-1 expression in Thy-1(-) cells in a time-dependent and concentration-dependent fashion and was associated with enrichment of histone acetylation. TSA treatment cancause Thy-1 depletion of trimethylated H3K27, concurrent with enrichment of trimethylated H3K4 and acetylated H4. Previously hypermethylated CpG sitesin the Thy-1 promoter region was demethylated by TSA. Thy-1 silencing is regulated by histone modifications in addition to promoter hypermethylation in lung fibroblasts. Additionally, alteration of histone modifications alters DNA methylation."